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Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain
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Biochimie
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2016
The Cellular and Molecular Landscapes of the Developing Human Central Nervous System
John C Silbereis
et al.
Neuron
2016
Efficient Docosahexaenoic Acid Uptake by the Brain from a Structured Phospholipid
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et al.
Molecular Neurobiology
2015
A dose response randomised controlled trial of docosahexaenoic acid (DHA) in preterm infants.
C T Collins
et al.
Prostaglandins Leukot Essent Fatty Acids
2015
Blood-brain barrier: a dual life of MFSD2A?
Zhao Z
et al.
Neuron
2014
MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusion
C Toufaily
et al.
Placenta
2012
Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) - Implications for dietary recommendations
Philippe Guesnet
et al.
Biochimie
2011
Lipidomics reveals a remarkable diversity of lipids in human plasma
Oswald Quehenberger
et al.
J Lipid Res.
2010
A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2
Cécile Esnault
et al.
Proc Natl Acad Sci USA
2008
The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity
Robert K McNamara
et al.
Prostaglandins Leukot Essent Fatty Acids
2008
Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors
Nicolas G Bazan
et al.
Trends Neurosci
2006
The role of essential fatty acids in development
William C Heird
et al.
Annu Rev Nutr
2005
Essential fatty acid transfer and fetal development
S M Innis
et al.
Placenta
2005
Preferential transfer of 2-docosahexaenoyl-1-lysophosphatidylcholine through an in vitro blood-brain barrier over unesterified docosahexaenoic acid
N Bernoud
et al.
Journal of Neurochemistry
2002
Characterization of plasma unsaturated lysophosphatidylcholines in human and rat
M Croset
et al.
Biochem J.
2000
The uptake and metabolism of plasma lysophosphatidylcholine in vivo by the brain of squirrel monkeys
D R Illingworth, O W Portman
et al.
Biochem J .
1972
Transport of lysolecithin by albumin in human and rat plasma
S Switzer
et al.
The Journal of Lipid Research
1965
Metabolism of glycerolipids. 2. The enzymatic acylation of lysolecithin
Lands W E
et al.
J Biol Chem.
1960
Maternal DHA and the development of attention in infancy and toddlerhood
John Colombo
et al.
Child Dev.
2004
J Lipid Res . 2010 Nov;51(11):3299-305. doi: 10.1194/jlr.M009449. Epub 2010 Jul 29.

Lipidomics reveals a remarkable diversity of lipids in human plasma

July 29, 2010
Oswald Quehenberger 1, Aaron M Armando, Alex H Brown, Stephen B Milne, David S Myers, Alfred H Merrill, Sibali Bandyopadhyay, Kristin N Jones, Samuel Kelly, Rebecca L Shaner, Cameron M Sullards, Elaine Wang, Robert C Murphy, Robert M Barkley, Thomas J Leiker, Christian R H Raetz, Ziqiang Guan, Gregory M Laird, David A Six, David W Russell, Jeffrey G McDonald, Shankar Subramaniam, Eoin Fahy, Edward A Dennis

1. Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0601, USA.

Abstract

The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test and physicians readily and regularly prescribe drugs that alter the levels of major plasma lipids such as cholesterol and triglycerides. Plasma contains many thousands of distinct lipid molecular species that fall into six main categories including fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, sterols, and prenols. The physiological contributions of these diverse lipids and how their levels change in response to therapy remain largely unknown. As a first step toward answering these questions, we provide herein an in-depth lipidomics analysis of a pooled human plasma obtained from healthy individuals after overnight fasting and with a gender balance and an ethnic distribution that is representative of the US population. In total, we quantitatively assessed the levels of over 500 distinct molecular species distributed among the main lipid categories. As more information is obtained regarding the roles of individual lipids in health and disease, it seems likely that future blood tests will include an ever increasing number of these lipid molecules.

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