Jennifer L LaBarre 1, Muraly Puttabyatappa 2, Peter X K Song 3, Jaclyn M Goodrich 4, Ling Zhou 5, Thekkelnaycke M Rajendiran 6 7, Tanu Soni 6, Steven E Domino 8, Marjorie C Treadwell 8, Dana C Dolinoy 1 4, Vasantha Padmanabhan 1 2 4, Charles F Burant 9 10

Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Center of Statistical Research, Southwestern University of Finance and Economics, Chengdu, Sichuan, China.
Michigan Regional Comprehensive Metabolomics Resource Core, Ann Arbor, MI, USA.
Department of Pathology, Michigan Regional Comprehensive Metabolomics Resource Core, Ann Arbor, MI, USA.
Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA. burantc@umich.edu.
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. burantc@umich.edu

Abstract

Major alterations in metabolism occur during pregnancy enabling the mother to provide adequate nutrients to support infant development, affecting birth weight (BW) and potentially long-term risk of obesity and cardiometabolic disease. We classified dynamic changes in the maternal lipidome during pregnancy and identified lipids associated with Fenton BW z-score and the umbilical cord blood (CB) lipidome. Lipidomics was performed on first trimester maternal plasma (M1), delivery maternal plasma (M3), and CB plasma in 106 mother-infant dyads. Shifts in the maternal and CB lipidome were consistent with the selective transport of long-chain polyunsaturated fatty acids (PUFA) as well as lysophosphatidylcholine (LysoPC) and lysophosphatidylethanolamine (LysoPE) species into CB. Partial correlation networks demonstrated fluctuations in correlations between lipid groups at M1, M3, and CB, signifying differences in lipid metabolism. Using linear models, LysoPC and LysoPE groups in CB were positively associated with BW. M1 PUFA containing triglycerides (TG) and phospholipids were correlated with CB LysoPC and LysoPE species and total CB polyunsaturated TGs. These results indicate that early gestational maternal lipid levels influence the CB lipidome and its relationship with BW, suggesting an opportunity to modulate maternal diet and improve long-term offspring cardiometabolic health.

Keywords

Early life

Maternal

LPC

Brain

Nutrition